P
post translational modification methylation
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<a href="http://www.creative-proteomics.com/services/Methylation.htm">post translational modification methylation</a> is mediated by methyltransferases, and S-adenosyl methionine (SAM) is the primary methyl group donor. Methylation occurs so often that SAM has been suggested to be the most-used substrate in enzymatic reactions afterATP. Additionally, while N-methylation is irreversible, O-methylation is potentially reversible.
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